高向东,男,48岁,博士学位,教授,博士生导师

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博士生,导师,学位,教授,博士
高向东,男,48岁,博士学位,教授,博士生导师

专业方向:微生物学,微生物遗传学,酵母遗传学

教育经历:

1995/09-1998/06,复旦大学,博士

1992/09-1995/07,中国科学技术大学,硕士 1987/09-1992/07,中国科学技术大学,学士

工作经历:

2006/08-至今:武汉大学生命科学学院

1999/08-2006/07:美国宾夕法尼亚大学医学院,博士后 1998/08-1999/07:美国佛蒙特大学医学院,博士后

近五年讲授课程

1. 遗传学(全英文教学):生物学国际班和弘毅班本科生必修课,54学时/ 2. 微生物遗传学:本科生专业选修课,36学时/ 3. 高级微生物学研究生专业必修课,54学时/

近五年承担科研项目:

1. 国家自然科学基金项目Ras信号传递途径下游效应分子Mhy1YlRim15在解脂耶氏酵母二型性转换中的功能与调控机制研究 (31570076, 2016-2019) 2. 国家自然科学基金项目:酿酒酵母极性生长关键调控分子Rho3的新调控因子、下游效应分子及功能的鉴定(31370124, 2014-2017)

近五年发表学术论文情况:

1. Liang S-H, Wu H, Wang R-R, Wang Q, Shu T, Gao X-D* (2017) The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica. Mol. Microbiol. 104(4):553-567. 2. Nie W-C, He F, Yuan S-M, Jia Z-W, Wang R-R, Gao X-D* (2017) Roles of an N-terminal coiled-coil-containing domain in the localization and function of Bem3, a Rho GTPase-activating protein in budding yeast. Fungal Genet. Biol. 99: 40-51. 3. Yuan S-M, Nie W-C, He F, Jia Z-W, Gao X-D* (2016) Kin2, the budding yeast ortholog of animal MARK/PAR-1 kinases, localizes to the sites of polarized growth and may regulate septin organization and the cell wall. PLoS ONE 11(4): e0153992. 4. Fei He, Wen-Chao Nie, Zongtian Tong, Si-Min Yuan, Ting Gong, Yuan Liao, Erfei Bi, Xiang-Dong Gao* (2015) The GTPase-activating protein Rga1 interacts with


Rho3 GTPase and may regulate its function in polarized growth in budding yeast. PLoS ONE 10(4): e0123326.

5. Huan Wu, Jia Guo, Ya-Ting Zhou, Xiang-Dong Gao* (2015) The anillin-related region of Bud4 is the major functional determinant for Bud4’s function in septin organization during bud growth and axial bud-site selection in budding yeast. Eukaryot. Cell 14(3): 241-251. 6. Yun-Qing Li, Min Li, Xiao-Feng Zhao, Xiang-Dong Gao* (2014) A role for the Rap GTPase YlRsr1 in cellular morphogenesis and the involvement of YlRsr1 and the Ras GTPase YlRas2 in bud-site selection in the dimorphic yeast Yarrowia lipolytica. Eukaryot. Cell 13(5): 580-590. 7. Min Li, Yun-Qing Li, Xiao-Feng Zhao, Xiang-Dong Gao* (2014) Roles of the three Ras proteins in the regulation of dimorphic transition in the yeast Yarrowia lipolytica. FEMS Yeast Res. 14(3): 451-463. 8. Yuan Liao, Fei He, Ting Gong, Erfei Bi, Xiang-Dong Gao* (2013) Msb1 interacts with Cdc42, Boi1, and Boi2 and may coordinate Cdc42 and Rho1 functions during early stage of bud development in budding yeast. PLoS ONE 8(6): e66321. 9. Ting Gong, Yuan Liao, Fei He, Yang Yang, Dan-Dan Yang, Xiang-Dong Chen, Xiang-Dong Gao* (2013) Control of polarized growth by the Rho family GTPase Rho4 in budding yeast: Requirement of the N-terminal extension of Rho4 and regulation by the Rho GTPase-activating protein Bem2. Eukaryot. Cell 12(2): 368-377. 10. Zhao X-F, Li M, Li Y-Q, Chen X-D, Gao X-D* (2013) The TEA/ATTS transcription factor YlTec1p represses the yeast-to-hypha transition in the dimorphic yeast Yarrowia lipolytica. FEMS Yeast Res. 13(1): 50-61.


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