散发型克罗伊茨费尔特-雅各布病患者的睡眠-觉醒紊乱

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伊茨,雅各布,克罗,费尔特,病患者
散发型克罗伊茨费尔特-雅各布病患者的睡眠-觉醒紊乱

Landolt; H.; -; P.; Glatzel; M.; Blaettler; T.; Bassetti; C.L.; 张嘉靖（译）

【期刊名称】《《世界核心医学期刊文摘：神经病学分册》》【年(卷),期】2006(2)9

【摘要】Background: The prevalence and characteristics of sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease (sCJD) are poorly understood. Methods: Seven consecutive patients with definite sCJD underwent a systematic assessment of sleep-wake disturbances, including clinical history, videopolysomnography, and actigraphy. Extent and distribution of neurodegeneration was estimated by brain autopsy in six patients. Western blot analyses enabling classification and quantification of the protease-resistant isoform of the prion protein, PrPSc, in thalamus and occipital cortex was available in four patients. Results: Sleep-wake symptoms were observed in all patients, and were prominent in four of them. All patients had severe sleep EEG abnormalities with loss of sleep spindles, very low sleep efficiency, and virtual absence of REM sleep. The correlation between different methods to assess sleep-wake functions (history, polysomnography, actigraphy, videography) was generally poor. Brain autopsy revealed prominent changes in cortical areas, but only mild changes in the thalamus. No mutation of the PRNP gene was found. Conclusions: This study demonstrates in sporadic Creutzfeldt-Jakob disease, first, the existence of sleep-wake disturbances similar to those

reported in fatal familial insomnia in the absence of prominent and isolated thalamic neuronal loss, and second, the need of a multimodal approach for the unambiguous assessment of sleep-wake functions in these patients.

【总页数】2页(P27-28)

【作者】Landolt; H.; -; P.; Glatzel; M.; Blaettler; T.; Bassetti; C.L.; 张嘉靖（译）【作者单位】不详; Neurologische; Universitatsklinik; Universitatsspitalzürich; Frauenklinikstrasse; 26; 8091; Zürich; Switzerland 【正文语种】中文【中图分类】R338.22 【相关文献】

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