口服阿奇霉素、口服及静脉红霉素治疗呼吸道支原体感染疗效及不良反应对比

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口服,阿奇,支原体,红霉素,霉素
口服阿奇霉素、口服及静脉红霉素治疗呼吸道支原体感染疗效

及不良反应对比

赵雁雄;施苏林;刘姗姗

【期刊名称】《中国生化药物杂志》【年(卷),期】2017(000)004

【摘要】目的对比分析呼吸道支原体感染患儿实施口服阿奇霉素治疗和口服红霉素治疗以及红霉素静脉滴注治疗的临床效果,并分析相关不良反应的发生情况.方法回顾性分析本院2015年1月～2016年3月收治的110 例呼吸道支原体感染患儿的临床资料,随机分为阿奇霉素口服治疗组(38 例)、红霉素口服治疗组(36 例)以及红霉素静脉滴注治疗组(36 例).比较3 组的疗效及不良反应.结果阿奇霉素口服治疗组的治疗有效率显著高于红霉素口服治疗组与红霉素静脉滴注治疗组,退热时间、啰音消失时间、咳嗽消失时间、住院天数均显著短于红霉素口服治疗组与红霉素静脉滴注治疗组,血清IL-8、TNF-α、hs-CRP 检测水平以及不良反应发生率均显著低于红霉素口服治疗组与红霉素静脉滴注治疗组,组间比较差异均具有统计学意义( P< 0.05),且上述指标红霉素口服治疗组与红霉素静脉滴注治疗组组间比较差异无统计学意义.结论与不同给药途径的红霉素治疗进行比较,在对呼吸道支原体感染患儿进行治疗的过程中,实施口服阿奇霉素治疗可以获得更好的临床效果,且不良反应发生率更低,是一种安全有效的治疗方案.%Objective To compare and analyze the clinical effect and adverse reaction of oral azithromycin,oral and intravenous erythromycin on the treatment of mycoplasma infection in respiratory tract.Methods In our hospital in January 2015～March 2016 year,clinical datas of 110 cases with mycoplasma infection in respiratory

tract in children were analyzed retrospectively.The total cases were randomly divided into the oral azithromycin treatment group(38 cases),oral erythromycin treatment group(36 cases)and erythromycin intravenous group(36 cases).The therapeutic effects and the adverse reactions were evaluated in the three groups.ResultsThe effective rate in the oral azithromycin group was significantly higher than that of the two other groups.The time of fever fading,rales and cough disappearance and the hospitalized day in the the oral azithromycin group were significantly shorter than that in the other two groups.Serum IL-8,TNF-alpha and hs-CRP level and the adverse reaction rate in the the oral azithromycin was significantly lower than that in the other two groups.The differences of all above the indexes were statistically significant(all P<0.05),the above index in the oral erythromycin group and erythromycin intravenous group was no statistical significance.Conclusion Compared with different medication route of erythromycin,it can get better results which oral azithromycin was used on the treatment of children with respiratory tract mycoplasma infection,the adverse reactions rate is lower,is a safe and effective treatment.

【总页数】3页(P376-378) 【作者】赵雁雄;施苏林;刘姗姗

【作者单位】宁波市北仑区小港医院儿科,浙江宁波 315800;浙江大学明州医院儿科,浙江宁波 31500;宁波市妇女儿童医院北院内科,浙江宁波 315000

【正文语种】中文【中图分类】R725.6 【相关文献】

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